β-榄香烯烃基硒醚的一锅法合成

One-Pot Synthesis of β-Elemene-13-yl Alkyl Selenides

常温下将硒用N2H4·H2O还原后与卤代烃反应得到对称二硒醚,不经分离直接用NaBH4还原,再与13-氯-β-榄香烯作用得到β-榄香烯烃基硒醚.此一锅法操作简便、条件温和、反应快速而且产率较高,是合成不对称硒醚的一种简便实用的方法.对化合物g的初步生物活性实验表明其具有显著的抗氧化作用.

A convenient and efficient procedure is described for the preparation of β-elemene-13-yl alkyl selenides by treatment of selenium with N2H4·HzO/RX/NaBH4/13-chloro-β-elemene sequentially in one-pot at room temperature. This method has several advantages such as simple operation, short reaction time, mild conditions and high yields. It also provides a convenient and efficient way to the synthesis of unsymmetrical dialkyl selenides. The preliminary bioassay showed that product g exhibited notable antioxidation activity.