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P53基因异常可干扰IGF-1R治疗前列腺癌疗效 被引量:1

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摘要 根据在美国西雅图Fred Hutchinson癌症研究中心进行的一项最新研究显示,当前正处于开发阶段的前列腺癌治疗方法——通过抑制胰岛素样生长因子(IGF)活性来激活其靶受体,有可能得到意想不到的结果,尤其是在肿瘤抑制基因P53已经受损的情况下。
出处 《国外药讯》 2008年第8期25-26,共2页 World Pharmaceutical Newsletter
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  • 1黄卫,杨冬华,汤绍辉.肝癌胰岛素样生长因子II基因启动子P3甲基化的检测及意义[J].暨南大学学报(自然科学与医学版),2004,25(6):708-712. 被引量:1
  • 2汤绍辉,杨冬华,黄卫,周鸿科,卢筱华,叶刚.人肝癌组织胰岛素样生长因子Ⅱ基因P4启动子甲基化变化及其意义[J].中华医学杂志,2006,86(8):565-567. 被引量:2
  • 3Jemal A. Cancer statistics[J]. CA Cancer J Clin, 2005(55): 10-30.
  • 4Muller S, Zirkel D, Westphal M, et al. Genomic imprinting of IGF-2 and H19 in human meningiomas[J]. Eur J Cancer, 2000, 36(5): 651-655.
  • 5Sayer RA, Lancaster JM, Pittman J, et al. High insulin-like growth factor-2(IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer[J]. Gynecol Oncol, 2005, 96(2): 355-361.
  • 6Lu L, Katsaros D, Wiley A, et al. The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer[J]. Clin Cancer Res, 2006, 12(4): 1208-1214.
  • 7Kim HT, Choi BH, Niikawa N, et al. Frequent loss of imprinting of the H19 and IGF2 genes in ovarian tumors[J]. Am J Med Genet, 1998, 80(4): 391-395.
  • 8Monand J, Zambetti GP, Olson DC, et al. The MDM2 oncogene product forms a complex with p53 protein and inhibits p53- mediated transactivation[J]. Cell, 1992(69): 1237-1245.
  • 9Jpark IY, Sohn BH, Choo JH, et al. Deregulation of DNA methyhransferases and loss of parental methylation at the insulin- like growth factor Ⅱ (Igf2)/H19 loci in p53 knockout mice prior to tumor development[J]. Cell Biochem, 2005, 94(3): 585-596.
  • 10Kawasaki T, Nosho K, Ohnishi M, et al. IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG Island methylator phenotype and p53 [J]. Neoplasia, 2007, 9(12): 1091-1098.

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