P53基因异常可干扰IGF-1R治疗前列腺癌疗效
被引量:1
摘要
根据在美国西雅图Fred Hutchinson癌症研究中心进行的一项最新研究显示,当前正处于开发阶段的前列腺癌治疗方法——通过抑制胰岛素样生长因子(IGF)活性来激活其靶受体,有可能得到意想不到的结果,尤其是在肿瘤抑制基因P53已经受损的情况下。
出处
《国外药讯》
2008年第8期25-26,共2页
World Pharmaceutical Newsletter
同被引文献13
-
1黄卫,杨冬华,汤绍辉.肝癌胰岛素样生长因子II基因启动子P3甲基化的检测及意义[J].暨南大学学报(自然科学与医学版),2004,25(6):708-712. 被引量:1
-
2汤绍辉,杨冬华,黄卫,周鸿科,卢筱华,叶刚.人肝癌组织胰岛素样生长因子Ⅱ基因P4启动子甲基化变化及其意义[J].中华医学杂志,2006,86(8):565-567. 被引量:2
-
3Jemal A. Cancer statistics[J]. CA Cancer J Clin, 2005(55): 10-30.
-
4Muller S, Zirkel D, Westphal M, et al. Genomic imprinting of IGF-2 and H19 in human meningiomas[J]. Eur J Cancer, 2000, 36(5): 651-655.
-
5Sayer RA, Lancaster JM, Pittman J, et al. High insulin-like growth factor-2(IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer[J]. Gynecol Oncol, 2005, 96(2): 355-361.
-
6Lu L, Katsaros D, Wiley A, et al. The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer[J]. Clin Cancer Res, 2006, 12(4): 1208-1214.
-
7Kim HT, Choi BH, Niikawa N, et al. Frequent loss of imprinting of the H19 and IGF2 genes in ovarian tumors[J]. Am J Med Genet, 1998, 80(4): 391-395.
-
8Monand J, Zambetti GP, Olson DC, et al. The MDM2 oncogene product forms a complex with p53 protein and inhibits p53- mediated transactivation[J]. Cell, 1992(69): 1237-1245.
-
9Jpark IY, Sohn BH, Choo JH, et al. Deregulation of DNA methyhransferases and loss of parental methylation at the insulin- like growth factor Ⅱ (Igf2)/H19 loci in p53 knockout mice prior to tumor development[J]. Cell Biochem, 2005, 94(3): 585-596.
-
10Kawasaki T, Nosho K, Ohnishi M, et al. IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG Island methylator phenotype and p53 [J]. Neoplasia, 2007, 9(12): 1091-1098.
-
1肖凤.P_(53)基因异常与肿瘤的关系[J].临床荟萃,1997,12(23):1064-1065.
-
2张青云,吕有勇,李铮,李文梅,崔建涛,邓国仁.人胃癌组织p53基因异常的筛选及序列测定[J].中华医学杂志,1995,75(3):173-173. 被引量:5
-
3李文惠.P53基因异常与肿瘤[J].兰州医学院学报,1996,22(4):74-74. 被引量:1
-
4王东旭,房殿春,杨仕明,刘为纹.胃癌组织端粒酶活性及p53基因异常的分析[J].中华病理学杂志,1999,28(1):49-50. 被引量:7
-
5许坚.p53基因异常与头颈部癌[J].肿瘤防治研究,1997,24(1):57-58.
-
6非霍奇金淋巴瘤临床研究[J].河南医学研究,2008,17(2):164-164.
-
7黄文阳,邱录贵.p53异常与B细胞非霍奇金淋巴瘤预后关系的研究进展[J].中华医学杂志,2010,90(44):3163-3165. 被引量:3
-
8王德华,高子芬,白逸秋,张惠信,许翔,廖松林.85例非小细胞肺癌中p53基因异常的预后价值[J].郧阳医学院学报,1998,17(2):65-68.
-
9孙迎娟,丁钰,董国英,孙坚萍,罗兵,郭英华.p53基因异常与胃癌发生发展的关系[J].诊断学理论与实践,2005,4(3):228-230.
-
10理由(摘译).长期吸烟可增加患乳腺癌的风险[J].中华医学信息导报,2005,20(22):9-9.