紫草油促进创面愈合与血管内皮生长因子表达的临床研究

Wound Healing Promotion by Arnebia Root Oil and Expression of Vascular Endothelial Growth Factor in Wounded Tissues

目的探讨紫草油促进创面愈合的分子学机制。方法115例皮肤创面感染患者分成两组:A组56例,创面应用紫草油换药,B组59例,创面消毒清创后凡士林纱布覆盖包扎,第3、7、14、21天应用免疫组化染色技术检测两组创面愈合过程中肉芽组织血管内皮生长因子(VEGF)的表达,并进行比较。结果两组疗效间差别有统计学意义(P<0.05);治疗后第3、7、14、21天时两组创面肉芽组织中VEGF阳性细胞数间差别均有统计学意义(P<0.05)。结论紫草油可以通过促进组织高表达VEGF加快创面愈合。

Objective To study the effect of arnebia root oil on the expression of vascular endothelial growth factor （VEGF） in wounded tissues, Methods One hundred fifteen patients with skin wound infection were divided into 2 groups. Group A （ n = 56） were given arnebia root oil dressing, group B （ n = 59 ） covered with debridement Vaseline gauze bandage, following wound disinfection. Immunohischemical staining was used to detect VEGF expression of granulation tissues in the wound healing process on days 3, 7, 14 and 21. Results Healing rates were higher in group A than in group B, VEGF expression of group A was higher than that of group B. VEGF expression was higher in earlier period of wound healing than in later. Conclusion Arnebia root oil can accelerate wound healing by promoting high expression of VEGF.