中药胃肠安对比格犬胃癌术后转移的抑制作用

Anti-Metastasis Effect of "Wei Chang An Decoction" on Postoperative Gastric Cancer in Beagle Dogs

目的:观察中药胃肠安对比格犬胃癌术后转移的防治作用。方法:以乙基硝基亚硝基胍(ENNG)致比格犬胃癌后手术切除建立胃癌术后模型,术后3周随机分为中药组、化疗组和模型组。中药组连续喂服胃肠安煎剂,化疗组每4周予1疗程FAM方案化疗,模型组不予任何药物干预。观察各组生存期、生存质量及复发转移率等。结果:中药组术后生存期、生存质量明显优于模型组和化疗组(P<0.05);对于各组生存2个月以上的复发转移率统计显示,中药组生存2个月以上者与模型组存在显著性差异(P<0.05),而化疗组与模型组之间无显著性差异。结论:中药胃肠安对胃癌术后比格犬的复发转移有一定的防治作用。

Objective： To investigate the anti-metastasis effect of ＂Wei Chang An Decoction＂ on postoperative gastric cancer in Beagle Dogs. Methods： The gastric cancer was induced by Ethyl nitro NTG （ENNG） and then removed by operation in Beagle dogs to establish the postoperative model of gastric cancer. After three weeks of operation, the dogs were randomized into herb group administered with ＂Wei Chang An Decoction＂ continuously, chemotherapy group treated with FAM regimen every 4 weeks and model control group without any treatment. The survival time, quality of life and rate of recurrence or metastasis of every group were observed respectively. Results： Both survival time and quality of life of the herb group were significantly superior to those of chemotherapy group and model control group （P 〈 0.05）.The rate of recurrence or metastasis of herb group was significantly lower than that of model control group （P 〈 0.05）, while there was no significant difference between the herb group and chemotherapy group. Condusion：＂Wei Chang An Decoction＂can play a certain role in prevention of recurrence or metastasis of postoperative gastric cancer in Beagle dogs.