原位肝移植病人术后细菌感染病原菌及耐药性的研究

Bacterial infection distribution and drug resistance after orthotopic liver transplantation patients

目的研究原位肝移植病人术后感染的主要病原菌分布及耐药情况,探讨防治方法。方法分析从67例原位肝移植病人术后各部位分离出的167株病原菌及药敏结果。结果67例肝移植病人分离的病原菌,革兰阴性杆菌82株,占49.1%,革兰阳性球菌79株,占47.3%,真菌6株,占3.6%。主要致病菌依次为金黄色葡萄球菌、阴沟肠杆菌和肺炎克雷伯菌。感染部位最常见呼吸道,其次为胆汁和腹腔引流液。其中有21例病人合并有两种以上病原菌感染。碳青霉烯类和糖肽类抗生素分别对革兰阴性杆菌和革兰阳性球菌有较高敏感性。结论感染是肝移植术后主要的并发症,合理、适当选用抗生素对降低肝移植病人术后感染,提高病人存活率非常重要。

[Objective] To explore main infectious bacteria distribution and their drug-resistance after orthotopic liver transplantation.[Methods] Analyzed drug-resistance of 167 strains bacteria from 67 orthotopic liver transplantation patients. [Results] 167 strains bacteria were isolated from 67 liver transplantation patients, including 82 Gstrains （49,1%）, 79 G＋ strains （47.3%）, 6 strains fungi （3.6%）, [Conclusions] To use antibiotics appropriately, it is very important to decrease the infections after livers transplantation.