数字短时记忆脑区定位的功能磁共振研究

Study of localizing brain regions related to short-term digital memory by functional magnetic resonance imaging

目的通过功能磁共振成像（functional magnetic resonance imaging，fMRI）技术研究健康人脑处理数字短时记忆的的脑区激活情况。方法12名右利手健康被试者进行一项数字短时记忆任务作业的同时进行fMRI扫描，试验采用组块设计并采用统计参数图（SPM99）软件进行数据分析和脑功能区定位。结果12名被试者数字短时记忆任务的正确率为（86．74±6．36）％。组分析统计阈值设定为P〈0．0001时，大脑皮层所激活的脑区有双侧枕叶、额叶、顶叶，皮层下结构有纹状体的激活；其中双侧枕叶的激活最为显著。结论人晒处理数字短时记忆信息是由大脑皮层下结构与大脑皮层一起共同完成的，并以语音和视觉双重编码。

Objective To examine the activation of brain regions in normal volunteers during short-term digital memory task by functional magnetic resonance imaging （fMRI） technique. Methods 12 right-handed normal volunteers participated in a test of short-term digital memory task,while the fMRI data were recorded. A control task was performed for the block-design. SPM 99 （ statistics parameter mapping 99） was used to analyze the data and to get the activated brain regions. Results When the threshold of the group analysis was set as P 〈 0. 0001, both cortex and subeortical structures were activated. The brain cortex areas including the bilateral occipital lobes,frontal lobes and parietal lobes were activated during the task, The subcortical structures including the lentiform nucleus and the caudate nucleus were also activated during the task. Meanwhile, the bilateral occipital lobes were the most prominently activated brain regions. Conclusion In human brain, the information of the sbon-term digital memory is manipulated by the collaborative activity between subcortical structures and cortex and employing phonological and visual coding.