老年抑郁症患者治疗前后血浆脑源性神经营养因子和组织纤维蛋白溶酶原激活物水平的变化

A study of brain-derived neurotrophic factor （BDNF） and tissue-type plasminogen activator （tPA） levels in geriatric depression

目的探讨老年抑郁症患者治疗前后血浆脑源性神经营养因子（Brain－derived neurotrophie factor，BDNF）和组织纤维蛋白溶酶原激活物（tissue－type plasminogen activator，tPA）水平的变化，为老年抑郁症的诊断和治疗提供生物学指标。方法用酶联免疫吸附法（ELISA）测定28例老年抑郁症患者治疗前后和30例正常对照组血浆中BDNF和tPA的水平，使用汉密尔顿抑郁量表（Hamilton Depression Rating Scale，HDRS）评分反映抑郁严重程度。结果与对照组[（958．83±150．20）pg／ml]比较，治疗前老年抑郁症患者血浆BDNF水平[（864．23±198．41）pg／ml]明显降低（P〈0．05），治疗后血浆BDNF水平[（929．99±150．90）pg／ml]有升高趋势；患者组治疗前[（13．33±5．35）ng／ml]、治疗后[（11．83±5．02）ng／ml]及正常对照组[（12．53±5．35）ng／ml]间tPA水平差异无显著性（P〉0．05）；治疗前血浆BDNF和tPA之间相关无显著性。结论BDNF可以作为老年抑郁症的一个生物学标记，tPA与BDNF之间可能存在复杂的中间调节过程。

Objective To investigate brain-derived neurotrophic factor（BDNF） and tissue-type plasminogen activator（tPA） levels in geriatric depression. Methods Plasma BDNF and tPA levels were determined in 28 patients with geriatric depression and 30 healthy controls by using ELISA. The severity of depression was measured with the Hamilton Depression Rating Scale （ HDRS ）. Results Plasma BDNF levels were significantly lower in patients with geriatric depression [ （ 864.23 ± 198.41 ） pg/ml ] than in normal control subjects [ （ 958.83 ± 150.20） pg/ml ] （ P 〈 0. 05 ） . There was a heightening tendency after treatment. There were no significant differences of tPA levels between pre-treatment [ （ 13.33 ± 5.35 ） ng/ml ], post-treatment [ （ 11.83 ± 5.02 ） ng/ml ] in patients with geriatric depression and in normal control subjects[ （ 12.53 ± 5.35 ） ng/ml ]. There were no significant correlations between BDNF and tPA in untreated patients with geriatric depression. Conclusions Plasma BDNF level in geriatric depression may be considered as a biological marker. There were a complicated mediated processes between BDNF and tPA.