摘要
目的探讨普通高中生不同学年血清儿茶酚胺、皮质醇及白细胞介素2、白细胞介素6水平的变化。方法用放射免疫法和磁性分离酶联免疫法对328名普通高中学生不同学年的血样中的分泌代谢指标肾上腺素（N）、去甲肾上腺素（NE）、皮质醇（CS）及免疫功能指标白细胞介素2（IL-2）、白细胞介素6（IL-6）含量进行测定，并与同时期职业高中生作对照组。结果普通高中学生随着高考时间临近，N、NE及cs值呈明显上升趋势，IL-2、IL-6则持续下降；高三时[N（268．5±119．5）pmol·L^-1，NE（1967．5±621．4）pmol·L^-1，CS（471．6±121．8）nmol·L^-1，IL-2（2．00±1．24）μg·L^-1，IL-6（0．193±0．06）μg·L^-1]与高二时比较（P〈0．01）、高一时比较（P〈0．01）及职高对照组比较（P〈0．01）各项生理指标均差异有显著性；高二时与高一时比较（t=1．96—2．52，P〈0．05）、与职高对照组比较（t=3．53—4．20，P〈0．01）各指标差异有显著性，高一时与职高对照组比较各指标差异无显著性（t=1．18—1．92，P〉0．05）。结论高三学生血浆N、NE及CS水平较高二时显著增高，而IL-2、IL-6水平显著下降。
Objective To observe the student＇ s endocrine metabolism in senior high school during different periods. Methods 328 senior middle school students in different periods were investigated and the blood concentration of adrenaline （ N ）, norepinephrine （ NE ）, cortisol （ CS）, interleukin-2 （ IL-2 ）, interleukin-6 （ IL-6 ） were measured by radioimmunoassay and Magnetic Solid Phase Separation-Enzyme Immunoassay, and at the same time; students in vocational high school were contrasted. Results As the university entrance examination was coming, the values of N,NE and CS were apparently rising, while the values of IL-2 and IL-6 were going down. The biochemical index of the students in senior middle school in Grade Three[ N （268.5 ± 119.5 ）pmol · L^-1, NE （1967.5 ±621.4）pmol · L^-1 ,CS（471.6 ± 121.8）nmol · L^-1,IL-2（2. 00 ± 1.24） μg · L^-1 ,IL-6（0. 193 ±0.06 ） μg · L^-1 ] and Grade Two （P 〈 0.01 ）, Grade One （P 〈 0.01 ） and the control （ P 〈 0.01 ） all had significant differences. Grade Two and Grade One （t = 1.96 - 2.52 , P 〈 0.05 ）, Grade Two and the control （t = 3.53 - 4.20 , P 〈 0.01 ） were different significantly, while Grade one and the control had no obvsious difference （t = 1.18- 1.92 , P 〉0.05）. Conclusion N, NE, CS of the senior high school students in Grade Three were higher, while IL-2 and IL-6 were lower than that of the Grade Two.
出处
《中国行为医学科学》
CSCD
2008年第8期751-752,共2页
Chinese Journal of Behavioral Medical Science
