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Cyr61在前列腺增生症患者膀胱壁中的表达及意义 被引量：1

The expression of Cyr61 in the bladder wall of benign prostatic hyperplasia
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摘要 目的探讨富半胱氨酸肝素结合蛋白61(Cyr61)在良性前列腺增生症(BPH)患者膀胱壁组织中的表达,评价Cyr61的表达和膀胱出口梗阻所致的膀胱壁纤维化之间的关系。方法分别留取BPH患者膀胱壁标本25例(BPH组)和非前列腺增生症且不伴有膀胱出口梗阻者膀胱壁标本19例(对照组),通过逆转录-聚合酶链反应(RT-PCR)和图像半定量分析,检测组织中Cyr61基因表达水平。结果BPH组膀胱壁组织中Cyr61 mRNA指数明显高于对照组(1.70±0.46vs.0.61±0.26,P<0.01)。结论Cyr61在BPH患者的膀胱壁组织中表达明显增高,可能是其纤维化的重要促进因素。 Objective To investigate the expression of cysteine - rich protein 61 （ Cyr61 ） in the bladder wall of benign prostatic hyperplasia （BPH） and to evaluate the relationship between Cyr61 gene expression and the fibrosis of bladder wall due to bladder outlet obstruction. Methods 25 samples of urinary bladder wall from BPH patients （ BPH group） and 19 samples from subjects without BPH and bladder outlet obstruction （control group） were obtained for expression level detection of Cyr61 in bladder wall by the reverse transcription polymerase chain reaction （ RT - PCR） and image semi - quantitative analysis. Results The Cyr61 mRNA index in bladder wall in BPH group was significantly higher than that in control group （1.70±0.46 vs. 0,61 ±0.26, P〈0.01）. Conclusion Cyr61 expression is significantly increased in the tissues of urinary bladder wall in BPH patients, which may contribute to the fibrosis of bladder wall in BPH and shed new light on the safe and effective therapy of BPH.
作者 朱海涛 王延虎 温儒民 孙晓青 张小东
机构地区 徐州医学院附属医院泌尿外科 首都医科大学北京朝阳医院泌尿外科
出处 《徐州医学院学报》 CAS 2008年第8期497-499,共3页 Acta Academiae Medicinae Xuzhou
基金 江苏省教育厅指导性课题(05KJD320230)
关键词 前列腺增生症 富半胱氨酸肝素结合蛋白61 膀胱出口梗阻 prostatic hyperplasia cysteine -rich protein 61 bladder outlet obstruction
分类号 R699 [医药卫生—泌尿科学]
  • 相关文献

参考文献7

  • 1Berry SJ, Coffey DS, Walsh PC, et al. The development of human benign prostatic hyperplasia with age [ J ]. J Urol, 1984,132 ( 3 ) : 474 - 478.
  • 2Chaqour B, Whitbeck C, Han JS, et al. Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction [J]. Am J Physiol Endocrinol Metab, 2002,283 (4) : E765 - E774.
  • 3王国民,王杭.雄性兔膀胱出口部分梗阻所致逼尿肌功能障碍的研究[J].中华实验外科杂志,2001,18(6):564-566. 被引量：9
  • 4Buttyan R, Chen MW, Levin RM. Animal models of bladder outlet obstruction and molecular insights into the basis for the development of bladder dysfunction [J]. Eur Urol, 1997,32 (Suppl 1 ) : 32 -39.
  • 5Mirone V, Imbimbo C, Longo N, et al. The detrusor muscle: an innocent victim of bladder outlet obstruction [J]. Eur Urol,2007, 51(1) :57 -66.
  • 6Schober JM, Lau LF, Ugarova TP, et al. Identification of a novel integrin αMβ2 binding site in CCN1 ( CYR61 ), a matricellular protein expressed in healing wounds and atherosclerotic lesions [J]. J Biol Chem,2003,278(28) :25808 -25815.
  • 7李东,周新,郑方,朱凤霞.Cyr61的研究进展[J].国外医学（临床生物化学与检验学分册）,2005,26(7):424-426. 被引量：6

二级参考文献19

  • 1王国民，上海预防医学杂志，1997年，15卷，107页
  • 2Chem M W，J Urol，1996年，155卷，732页
  • 3Haugaard N，Neurourol Urodynam，1993年，12卷，473页
  • 4Jay P, Berge-Lefranc JL, Marsollier C, et al. The human growth factor-inducible immediate early gene, CYR61,maps to chromosome 1p. Oncogene, 1997, 14 (14) : 1753-1757.
  • 5Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett, 1993, 327(2): 125-130.
  • 6Wong M, Kireeva ML, Kolesnikova TV, et al. Cyr61,product of a growth factor-inducible immediate-early gene,regulates chondrogenesis in mouse limb bud mesenchymal cells. Dev Biol, 1997, 192(2): 492-508.
  • 7Mo FE, Muntean AG, Chen CC, et al. CYR61 (CCN1) is essential for placental development and vascular integrity.Mol Cell Biol, 2002, 22(24): 8709-8720.
  • 8Lechner A, Schutze N, Siggelkow H, et al. The immediate early gene product hCYR61 localizes to the secretory pathway in human osteoblasts. Bone, 2000, 27(1): 53-60.
  • 9Chen CC, Chen N, Lau LF. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem, 2001,276(13): 10443-10452.
  • 10Chen CC, Mo FE, Lau LF. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem, 2001, 276(50): 47329-47337.

共引文献13

同被引文献25

  • 1丁砺蠡,熊恩庆,龚宇,宋波.膀胱出口梗阻体外细胞生物力学模型的建立的研究[J].第三军医大学学报,2005,27(10):968-971. 被引量：1
  • 2范立新,宋波,李龙坤,金锡御,文前军,李蕾.正常与不稳定大鼠膀胱逼尿肌T型Ca^(2+)通道亚型对比研究[J].第三军医大学学报,2005,27(13):1345-1347. 被引量：1
  • 3Miyazato M, Sugaya K, Nishijima S, et al. Changes of bladder aetivity and connexin 43-derived gap junctions after partial bladder-outlet obstruetion in rats[J]. Int Urol Nephrol, 2009, 41: 815-21.
  • 4John H, Walch M, Lehmann T, et al. Connexin45 expression in thehuman obstructed detrusor muscle[J]. World J Urol, 2009, 27:411- 8.
  • 5Gillespie JI, Markerink-van IM, De Vente J. Interstitial cells and cholinergic signalling in the outer muscle layers of the guinea-pig bladder[J]. BJU Int, 2006, 97: 379-85.
  • 6Zhu Y, Shi B, Xu Z, et al. Are TGF-betal and bFGF correlated with bladder underactivity induced by bladder outlet obstruction[J]. Urol Int, 2008, 81: 222-7.
  • 7Grol S, Essers PB, van KGA, et al. Ubiquitin hydrolase (protein gene product 9.5) in the obstructed bladder: evidence for tissue remodelling involving a subset of interstitial cells[J]. BJU Int, 2009, 104: 698-706.
  • 8Mannikarottu AS, Disanto ME, Zderic SA, et al. Altered expression of thin filament-associated proteins in hypertrophied urinary bladder smooth muscle[J]. Neurourol Urodyn, 2006, 25: 78-88.
  • 9Chang S, Gomes CM, Hypolite JA, et al. Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein[J]. Am J Physiol Renal Physiol, 2010,298:F1416-23.
  • 10Kita M, Yunoki T, Takimoto K, et al. Effects of bladder outlet obstruction on properties of Ca2+-activated K+ channels in ratbladder[J], Am J Physiol Rcgul Integr Comp Physiol, 2010, 298: R1310-9.

引证文献1

二级引证文献7

徐州医学院学报
2008年 第8期

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