交让木属植物中生物碱类化合物的研究进展

Recent Research Progresses on Alkaloids from Genus Daphniphyllum

生物碱广泛存在于自然界,是科学家们研究最早的一类有生物活性的天然有机化合物。随着植化分离和结构鉴定手段的提高,越来越多的生物碱类化合物被从交让木属植物中分离鉴定出来,近年来已鉴定80余种化合物。为了更好地开发和利用本属植物,作者在查阅国内外文献的基础上就这一领域的研究进展进行了综述。

Alkaloids are natural organic compounds that were the most early studied by scientists and most of them have good bioactivities. Plants of the genus Daphniphyllum are known to metabolize structurally diversified Daphniphyllum alkaloids with highly complex polycyclic skeleton. Daphniphyllum alkaloids have been the challenging subjects in biogenetic and synthetic programs of natural products. Some of these alkaloids exhibited cytotoxic activities against several tumor cell lines. Along with the developments of isolation and structure elucidation techniques of phytocbemistry, more and more compounds of this genus were isolated and identified. More than 70 compounds were obtained from this genus of plants in recent research. In order to assist the medicinal application of this genus of plants, progresses made in this field were systemically reviewed, which will be benefitial for further research and development of these compounds.