不同空腹血糖水平胰岛素抵抗及相关因素分析

The study of insulin resistance and correlation risk factors in the pre-diabetic patients and health subjects

目的对不同空腹血糖(FPG)状态下胰岛素抵抗(IR)的相关因素进行分析。方法将258例研究者分为四组:A组为FPG≤5.0mmol/L者65例;B组为5.0mmol/L<FPG<5.6 mmol/L者67例;C组为5.6mmol/L≤FPG<6.1mmol/L者64例;D组为6.1mmol/L≤FPG<7.0mmol/L者62例。测定FPG、空腹胰岛素(FIns)和血脂等生化指标,并进行统计学分析。结果(1)各组内甘油三酯(TG)、TG/高密度脂蛋白(HDL-C)值男性均高于女性(P<0.01,P<0.05);各组间TG、TG/HDL-C值有统计学意义(P<0.05)。(2)各组间FPG、胰岛素抵抗指数(Hom a-IR)有统计学意义(P<0.01)。(3)FPG、TG、TG/HDL-C与Hom a-IR正相关(P<0.01)。结论随着FPG增加,IR和TG代谢紊乱加重,IR与FPG、TG、TG/HDL-C比值呈正相关。

Objective To study insulin resistance （IR） in the different levels of fasting plasma glucose （ FPG）, and to analyze their eorrelateion with IR. Methods According to the levels of FPG, 258 subjects were divided into Group A： （ FPG ≤5.0mmol/L, n = 65 ） ; Group B ： （5.0mmol/L 〈 FPG 〈 5.6 mmol/L, n = 67） ; Group C： （5.6mmol/L ≤ FPG 〈 6.1 mmol/L, n = 64） ; Group D： （6. lmmol/L≤FPG 〈7.0 mmol/L, n =62）. The levels of FPG, fasting insulin （Fins）, fasting lipids in four groups were detected . The serum markers were studied. Results （ 1 ） TG and TG/HDL - C were higher in male groups than the female groups in four groups （P 〈0.01, P 〈0.05）. TG and TG/HDL-C were significantly differed in four groups （P〈0.05）. （2） In four groups, FPG and Homa - IR were significantly differed （P 〈0.01 ）. （3） FPG, TG and TG/HDL - C was significantly correlated with Homa - IR （P 〈 0.01 ）. Conclusion With FPG increasing, the severities of IR and dyslipidemia are increased. IR is correlated with FPG, TG and TG/ HDL - C.