摘要
The RuCl2(PPh3)3/γ-Al2O3 catalyst modified by chiral reagent(1S,2S)-(-)-1,2-diphenyl-1,2-ethylenediamine((1S,2S)-DPEN) was investigated for the asymmetric hydrogenation of acetophenone and its derivatives.At the optimized reaction conditions,85% conversion of acetophenone and 82%e.e.of(R)–α-phenyl ethanol were achieved over RuCl2(PPh3)3/γ-Al2O3 catalyst modified by(1S,2S)-DPEN.Furthermore,the results indicated that there was a synergistic effect between(1S,2S)-DPEN and KOH,which significantly accelerated the reaction rate and enantioselectivity.
The RuCl2 （ PPh3 ） 3/γ-Al2O3 catalyst modified by chiral reagent （ 1S, 2S） - （-） - 1,2 -diphenyl- 1,2-ethylenediamine （ （ 1 S, 2S）-DPEN） was investigated for the asymmetric hydrogenation of acetophenone and its derivatives. At the optimized reaction conditions,85 % conversion of acetophenone and 82% e. e. of （R） - α-phenyl ethanol were achieved over RuCl2 （ PPh3 ） 3/γ-Al2O3 catalyst modified by （1S ,2S）-DPEN. Furthermore,the results indicated that there was a synergistic effect between （1S,2S）-DPEN and KOH,which significantly accelerated the reaction rate and enantioselectivity.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2008年第8期1050-1055,共6页
Chemical Research and Application
关键词
钌膦配合物
苯乙酮
不对称加氢
对映选择性
ruthenium phosphine complexes
acetophenone
asymmetric hydrogenation
enantioselectivity
