摘要
为探讨小柴胡汤对鼠肝纤维化的抑制作用，腹腔分别注射二甲基亚硝基胺和猪血清复制两种肝纤维化动物模型。预防和治疗性投与小柴胡汤可促进肝维生素A含量恢复，降低肝胶原含量和明显抑制肝前α－Ⅰ型胶原的基因表达。同时免疫组化染色证实小柴胡杨可显著减少Ⅰ、Ⅲ型胶原在肝脏沉积和明显减少α-平滑肌原纤维阳性的伊东细胞（ItoCell）的数目。结果显示小柴胡汤可防治鼠肝纤维化的发生与发展。
To investigate the fibrosuppressive role of xiao chai Hu Tang, hepatic fibrosis modelswere induced by a single injection of dimethylnitrosamine (DMN) or pig serum (PS). Both preventiveand therapeutic administration of xiao chai Hu Tang could significantly enhance the recovery of retinylpalmitate (RP) contents, reduce hepatic collagen contents and remarkably inhibit hepatic pro-alpha 1(I) collagen gene expression. Immunohistochemical examination revealed that xiao chai Hu Tangcould also decrease the deposition of type Ⅰ and Ⅲ collagens and the number of alpha-smooth muscleactin (α-SMA) positive Ito cells in the liver evidently. These results suggest that xiao chai Hu Tangcan prevent and treat the occurrence and development of hepatic fibrosis in rats.
出处
《泸州医学院学报》
1997年第2期81-86,共6页
Journal of Luzhou Medical College
关键词
肝纤维化
中医药疗法
小柴胡汤
实验药理
xiao chai Hu Tan
Fibrosis
Dimethylnitrosamine
Pig serum
Ito cell
