早期气管插管抢救急性重度有机磷农药中毒合并呼吸衰竭的疗效分析

The clinical analysis of early tracheal intubation to rescue acute serious organophosphate poisoning combined with respiratory failure

目的探讨早期气管插管抢救急性重度有机磷农药中毒(ASOPP)并呼吸衰竭的临床价值。方法回顾性分析我院2005～2007年收治的急性重度有机磷农药中毒合并呼吸衰竭患者(插管组)34例和2005～2006年(非插管组)32例的临床资料,比较两组患者的住院时间(入住EICU时间)、复能剂的用量、治愈率、病死率。结果①早期插管组住院时间明显短于非插管组、复能剂的用量明显减少(P<0.01);②早期院内插管组的治愈率显著高于非插管组、病死率显著降低(P<0.05),而早期院前插管组的治愈率、病死率与非插管组相比差异无统计学意义(P>0.05)。结论早期气管插管是抢救ASOPP并呼吸衰竭的有效措施,有助于改善患者的预后。

Objective To evaluate the value of early tracheal intubation to rescue acute serious organophosphate poisoning（ ASOPP） combined with respiratory failure. Methods 34 cases acute serious organophosphate poisoning combined with respiratory failure from 2005～2007 （ early intubation group） and 32 cases from 2005～2006 （ non-intubation group） were received retrospectively. The hospitalization time, dosage of pyridine aldoxime methyliodide（ PAM ）, cure rate, mortality were compared with non-intubation group. Results The hospitalization time was shorter, dosage of PAM saller compared with the non-intubation group （ P 〈 0.01 ） . The mortality significantly decreased in the early in-hospital intubation group, cure rate significantly increased compared with the non-intubation group（ P 〈 0.05 ）, But no significantly difference in the early pre-hospital intubation group （P 〉 0.05 ）. Conclusion Early tracheal intubation was an effecttive measure to rescue ASOPP and improved prognosis.