食管癌患者手术前后血清sIL-2R的动态观察及意义

DYNAMIC STUDY OF SERUM sIL-2R LEVELS OF ESOPHOGEAL CARCINOMA BEFORE AND AFTER OPERATION AND ITS SIGNIFICANCE

采用ELISA夹心法对食管癌患者手术前后血清可溶性白细胞介素2受体（sIL－2R）水平进行了动态观察，结果发现，有手术指征的食管瘤患者组血清sIL－2R水平（407±99u／ml）非常显著地高于正常对照组（265±88u／ml）（P＜0．001），其中Ⅰ、Ⅲ组食管癌患者手术前后血清sIL－2R水平明显下降（Ⅰ组：术前；375±52u／ml术后：259±39u／ml；Ⅲ组：术前：383±73u／ml术后：260±64u／ml），而Ⅲ组病人手术前后血清sIL－2R水平无明显差异；部分术后追踪观察发现，复发者血清sIL－2R水平（959±143u／ml）与未复发者（345±78u／ml）有显著性差异（P＜0．001）．该研究结果说明血清sIL－2R水平在指导外科医生明确手术指征，选择手术方式、估计预后上有较为重要的参考价值。

Dynamic observation was made on the level of serum soluble interleukin 2 receptor(sIL2R) by ELISA method before and after operation on patients with operable esophageal carcinoma. Itwas found that serum sIL-2R of patients (407±99u/ml) was very stringly higher than that ofhealthy controls (265±88u/ml) (P<0. 001). These patients were divided into three groupsaccording to pathological severity. In Group Ⅰ and Ⅱ sIL-2R distinctly decreased after operation (Group Ⅰ:375 ±52u/ml pre-operation; 259±39u/ml post-operation;Group Ⅱ: 383±73u/ml pre operation;260±64u/ml post-operation), no distinct difference was found in Group Ⅲ. In some follow-ups, itwas discovered that the level of recurrent patients (959±143u/ml) was significantly higher than thatof un-recurrent ones (345±78u/ml) (P<0. 001). The results suggested that the serum sIL-2R levelmight provide surgeons with important reference in selecting operative ndication, operative method,and in anticipating prognosis.