奥生多龙的合成

Synthesis of Oxendolone

以雌酚酮（Ⅱ）为原料，经８步反应合成奥生多龙（Ⅰ）。化合物Ⅴ与乙基溴化镁反应时，Ｃ１６位未引入乙基，而引入了溴（Ⅺ），其结构经ＩＲ，１ＨＮＭＲ，ＭＳ及化学方法确证。

Oxendolone was synthesized from estrone(Ⅱ) via a eight step process. Compound(Ⅴ) reacted with ethyl magnesium bromide to give compound(Ⅺ) while the expected compound(Ⅸ) did not obtained. The structure of compound(Ⅺ) was identified by elemental analysis, IR, 1HNMR and MS.