头孢哌酮合成工艺的改进

Improvement on Synthesis of Cefoperazone

以７－ＡＣＡ为起始原料，经与１－甲基四氮唑－５－硫醇缩合，再与Ｄ－（－）－２－（４－乙基－２，３－二氧代－１－哌嗪酰胺）－２－（４－羟基－苯基）－醋酸缩合得头孢哌酮。方法Ａ和方法Ｂ的总收率分别为３８．２％和３４．２％。

Cefoperazone was synthesized in two steps. The synthetic method, especially the subsequent disposal method,was improved by recrystallization from mixed solvent of acetonitrile and water. The overall yield of method A and method B were 38.2% and 34.2% respectively.