周围神经损伤修复中Meissner小体的退变与再生

Degeneration and Regeneration of Meissner Corpuscles

目的：通过观察Ｍｅｉｓｎｅｒ小体的退变与再生过程，以评价修复晚期周围神经损伤恢复感觉功能的临床价值．方法：将恒河猴的示，中，环，小指随机分成四组，切断指神经后第８，１２，３０，５０周光镜观察Ｍｅｉｓｓｎｅｒ小体退变过程；第１２、３０周修复神经，修复后５０周观察再生情况．结果：Ｍｅｉｓｓｎｅｒ小体在失神经３０周基本完全退变．１２周修复组再生神经纤维可以重新长入残存的小体，使其恢复基本结构．３０周修复组新生的神经纤维以游离神经末梢的形式恢复感觉功能．但是不能形成新的Ｍｅｉｓｓｎｅｒ小体．结论：实验结果为修复晚期周围神经损伤提供了理论依据．

Aim: We have studied the degeneration and regeneration of the Meissner corpuscles in order to estimate the clinical value of the delayed repair of peripheral nerve injuries. Methods: The specimens were taken in 8, 12, 30, 50 weeks after transections of the digital nerves respectively. Also we repaired the transected nerves 1 and 30 weeks after transection and took the specimens 50 weeks after repairment to observe the regeneration of Meissner corpuscles. Results: The regeneration nerve fibre was seen growing into the remained Meissner corpuscles to repair nerves in the 12 week repairment group. And no Meissner corpuscles were found in the 30 week repairment group. The regenerated nerve fibre recovered its sensory function in the form of free nerve endings in the repaired nerves in 30 weeks, but it is impossible for the Meissner corpuscles to regenerate. Conclusion: The results of this experiment provided a theoretical basis for repairing peripheral nerve injuries in late stage.