P^(53)表达与胃癌浸润转移的关系

THE RELATIONSHIP BETWEEN THE EXPRESSION OF P^(53) AND INVASION AND METASTASIS OF HUMAN GASTRIC CARCINOMA

为了研究胃癌浸润转移的机理,应用免疫组化方法,选择抗P^(53)蛋白产物抗体Pab1801检测14例胃癌手术切除标本新鲜冰冻切片中P^(53)蛋白产物的表达,发现阳性率为42.8％,仅在肿瘤细胞核上表达,并有异质性表达。P^(53)阳性与淋巴结转移密切相关。因此Pab1801可以作为胃癌转移的标志物。

In order to explore the mechanisms of gastric carcinoma invasion and matastasis using immunohistochemistry (ABC Pah 1801 method). the expression and distribution of P53 gene product in 14 specimens of gastric carcinoma crystal sections of fresh speci mens had been studied. Six of the carcinoma (42. 8%) showed positive staining that is confined to neoplastic nuclei; but its ex pression was heterogeneous. The postivity was correlated with the lymph node metastasis. Therefore P53 is a valuable marker for evaluating gastric carcinoma metastasis.