多烯紫杉醇联合顺铂治疗晚期乳腺癌疗效观察

Clinical observation of docetaxel with DDP treating advanced breast cancer

目的:观察国产多烯紫杉醇(艾素)联合顺铂治疗晚期乳腺癌的疗效及毒副反应。方法:21例患者均有病理学诊断及可评价的客观指标。采用多烯紫杉醇35mg/m2,静脉滴注1h,第1天、第8天及第15天,顺铂(DDP)为30mg/m2静脉滴注,第2天、第3天及第4天,28d为1个周期,所有患者均至少接受2个周期的化疗。结果:完全缓解(CR)1例,部分缓解(PR)11例,总有效率57.14%。主要毒副反应为骨髓抑制和脱发。结论:多烯紫杉醇联合顺铂治疗晚期乳腺癌有效率较高,毒副反应较小,值得临床进一步研究。

Objective：To observe the effects and toxicity of docetaxel plus DDP in treatment of advanced breast cancer. Methods：The 21 patients with a pathologic diagnosis of advanced breast cancer. The chemotherapy regimen was comprised of docetaxel 35 mg/m^2 intrav-enously dropped for 1 hours,d 1,8,15,DDP 30 mg/m^2 intraveno-usly dropped d2,3,4,repeated every 4 weeks. All patients were received at least two cycles of the treatment. Results：The remission rate was 57.14% including CR1 case,PRll cases. The major toxicities included neutropenia and alopecia. Conclusion ：Docetaxel combined with DDP has high efficiency and low toxicities in the treatment of advanced breast cancer. It is worthy of further clinical observation.