VEGF及CD105在结直肠癌中的表达及其意义

The expression and significance of vascular endothelial growth factor and CD105 in colorectal carcinoma

目的探讨在结直肠癌中血管内皮生长因子(VEGF)的表达及CD105标记的微血管密度(MVD)的计数,及两者与病理参数的关系。方法应用免疫组织化学方法检测60例结直肠癌及60例正常结肠组织中VEGF及CD105的表达。结果结直肠癌中VEGF表达的阳性率为68.3%,MVD值为36.50±9.43,与正常结肠组织中VEGF表达的阳性率(0)及MVD值(16.68±7.65)比较差异有统计学意义(均P<0.01)。VEGF的表达及MVD与浸润深度、Dukes分期及有无淋巴结转移密切相关。结论VEGF参与结直肠癌的血管生成,且与预后有一定关系。

Objective To study the expression of vascular endothelial growth factor （VEGF）and the count of microvessel density（MVD） which is stained by CD105 in colorectal carcinoma and their relationships with pathological parameters. Methods The expressions of VEGF and CD105 protein in colorectal carcinoma tissues obtained from 60 patients who underwent radical resection and the normal tissues of 60 cases were detected by immunohistochemical methed （IHC）. Results VEGF protein was expressed in 68. 3% of patients, and MVD was 36. 50 ± 9. 43. Compared with the normal tissues, the expression of VEGF and MVD were significantly different （all P 〈0. 01 ）and correlated with penetrating depth, lymph node metastasis and Dukes stage. Condusions VEGF may be related to angiogenesis and prognosis in colorectal carcinoma.