重型再生障碍性贫血Ⅰ型和Ⅱ型患者的移植疗效比较

Comparison of transplant effect between severe aregenerative anemia-Ⅰ and severe aregenerative anemia-Ⅱ patients

目的比较非清髓性造血干细胞移植(NSCT)对重型再生障碍性贫血(SAA)Ⅰ型及Ⅱ型患者的临床疗效及安全性。方法对32例SAA患者行NSCT,预处理主要采用小剂量环磷酰胺、抗淋巴细胞球蛋白或抗胸腺细胞球蛋白;移植后采用环孢菌素、骁悉预防移植物抗宿主病。结果与SAAⅡ型患者比较,SAAⅠ型患者造血重建迅速、植入率高、并发症少且轻,预后佳,生存率高。结论NSCT是治疗SAAⅠ型患者及一般情况良好且输血制品次数少的SAAⅡ型患者的治疗首选。

Objective To compare the clinical therapeutic effect and security of NSCT on severe aregenerative anemia （SAA） - Ⅰ and SAA- Ⅱ patients. Methods 32 SAA patients received NAST after pretreatment of small dose cytoxan, antilymphocytic globulin, antithymocyte globulin, Cyclosporine and cellcept were applied to prevent graft versus host disease. Results Compared with SAA-Ⅱ patients, the SAA-Ⅰ patients had quick haematopoiesis reconstruction, high imbedding rates, few and light complications, good prognosis and high survival rates. Conclusions NSCT is the chief selection of SAA-Ⅰ patients and the SAA-Ⅱ patients whose general state is good and the times of blood infusion are few.