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应变率成像技术评价柔红霉素化疗对ALL患儿左心功能的影响

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摘要 将36例急性淋巴细胞白血病(ALL)患儿(观察组)按照柔红霉素(DNR)化疗累积量是否超过200mg/m2分为A、B两组,用应变率成像(SRI)技术检测其化疗前后及正常对照组的左心功能。结果显示,观察组E/A、左室短轴缩短率、左室射血分数均低于对照组(但无统计学差异),二尖瓣环舒张早期运动速度/舒张晚期运动速度低于对照组(P<0.05)。A组左室心肌的收缩期峰值应变率(SPSR)及舒张期峰值应变率(EDPSR)均明显低于对照组(P均<0.05),A、B组化疗前后SPSR及EDPSR均无统计学差异。提示SRI技术可较敏感地监测DNR对ALL患儿左心功能的损害。
出处 《山东医药》 CAS 北大核心 2008年第25期40-41,共2页 Shandong Medical Journal
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