复方首乌降脂通脉颗粒防治大鼠高脂血症和脂肪肝的实验研究

Studies of the effects of complex Shouwu jiangzhitongmai granule on experimental hyperlipidemia and fatty liver in rats

目的:研究复方首乌降脂通脉颗粒对大鼠高脂血症和脂肪肝的防治作用。方法:大鼠在小剂量四氯化碳致肝损伤的基础上,合并喂养高脂饲料复制大鼠脂肪肝模型。防治给药组分别给予不同浓度的药物,以血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、丙二醛(MDA)和超氧化物歧化酶(SOD)含量为评价指标,观察药物的防治效果。结果:与大鼠脂肪肝模型组相比,复方首乌降脂通脉颗粒可以显著降低大鼠血清TC、TG、LDL、MDA、ALT和AST含量,升高SOD活性。肝脏组织及病理形态学改变均有明显的改善。结论:复方首乌降脂通脉颗粒能明显降低高脂血症大鼠的血脂水平,减轻脂肪肝形成的程度,对复合因素引起的脂肪肝有较好的防治作用。

Objective To investigate the antihyperlipidemia and antifatty liver of complex Shouwu jiangzhitongmai granule （CSJG） in rats. Methods Male SD rats were fed with high-fat diet for 6 weeks after being treated with low dose of carbon tetrachloride （CCl4） to induce the fatty liver model. The different dosages of the drug were then orally given to the rats. Serum contents of total cholesterol （TC）, triglycerides （TG） ,high-density lipoprotein （HDL） ,low-density lipoprotein （ LDL）, alanine transaminase （ ALT）, aspartate transaminase （AST）, malonyldialdehyde （ MDA）, and superoxide dismutase （SOD） were measured as indexes to evaluate the drug effects. Results The serum levels of TC, TG, LDL, MDA, ALT, and AST were significantly decreased and the activity of SOD was markedly increased by the CSJG. The substantial improvement of liver histology and the pathological morphology were also observed in treated rats. Conclusion CSJG can significantly reduce the levels of serum lipids as well as alleviate the degree of fatty liver formation,indicating that it has great effects on the experimental fatty liver induced by administration of the combination of a low dose CCl4 and high-fat diet.