摘要
目的:探讨外周血骨桥蛋白(osteopontin,OPN)作为胃癌肿瘤标志物检测的临床意义。方法:应用酶联免疫吸附试验(ELISA)和放射免疫分析技术(RIA)检测63例胃癌患者手术前后外周血OPN和癌胚抗原(carcinoembryonic antigen,CEA)的质量浓度,对照组为40例正常健康志愿者。结果:胃癌患者外周血OPN和CEA检测的敏感性分别为69.8%和57.1%,特异性分别为92.5%和87.5%,联合检测的敏感性为77.8%。OPN和CEA的质量浓度与胃癌的临床分期、淋巴结和器官转移有关,与胃癌的组织学分型及大小无关。治疗前后两种标志物的质量浓度具有显著差异。结论:OPN是一种较为理想的胃癌肿瘤标志物,与CEA联合检测能提高胃癌诊断的敏感性。
Objective To evaluate the clinical significance of osteopontin (OPN) as a tumor marker in peripheral blood of patients with gastric cancer. Methods Serum levels of OPN and carcinoembryonic antigen (CEA) in gastric cancer (n = 63) in pre- and post-operation and in control group (n =40) were detected by ELISA and RIA methods. Results The sensitivity of OPN and CEA in patients with gastric cancer was 69. 8% and 57. 1%, and the specificity of OPN and CEA was 92.5% and 87.5%, respectively. The sensitivity of OPN combined with CEA was 77.8%. Serum levels of OPN and CEA were related with PTNM stage, lymph node involvement and presence of distant metastases and not related with histological type and size. Pre-and post-operative levels of the two markers were obviously different. Conclusion OPN, a potential tumor marker, improves the sensitivity of diagnosis of gastric cancer when combined with CEA.
出处
《东南大学学报(医学版)》
CAS
2007年第4期243-245,共3页
Journal of Southeast University(Medical Science Edition)
基金
江苏省自然科学基金资助项目(BK2005070)
关键词
胃癌
骨桥蛋白
肿瘤标志物
gastric cancer
osteopontin
tumor marker