Galectin-3 VEGF Ki-67 MVD在青年乳腺癌淋巴结转移灶中的表达及意义

Expression and Significance of Galectin-3,VEGF,Ki-67,and MVD in Metastatic Lymph Nodes from Breast Cancer in Young Women

目的:探讨青年乳腺癌淋巴结转移灶Galectin-3、VEGF、Ki-67、MVD的表达及意义。方法:应用免疫组化SP法检测35例青年乳腺癌淋巴结转移灶(青年组)和35例其它年龄组乳腺癌淋巴结转移灶(对照组)Galectin-3、VEGF、Ki-67、MVD的表达情况。结果:Galectin-3在青年组的表达水平明显高于对照组(P<0.01),而VEGF的表达水平在两组之间无明显差异(P>0.05);青年组Ki-67和MVD明显高于对照组,差异有极显著性(P<0.01和P<0.01)。Galectin-3表达与Ki-67和MVD呈显著正相关(P<0.01和P<0.01)。结论:Galectin-3可能参与了瘤细胞的增殖和血管形成;青年乳腺癌淋巴结转移灶的癌细胞有更强的增殖、浸润和血管形成能力,这是青年乳腺癌恶性度高,预后差的重要因素。

Objective： To investigate the expression of Galectin-3, VEGF, Ki-67, and MVD in metastatic lymph nodes of breast cancer in young women and to explore the clinical significance of these indices. Methods： We used immunohistochemistry to detect the expression of Galectin-3, VEGF, Ki-67 and MVD in 35 samples of metastatic lymph nodes from breast cancer in young women and 35 samples of metastatic lymph nodes from breast cancer in women at other ages. Results： Galectin-3 expression in the young women group was significantly higher than that in the control group （P〈0.01）. No significant difference was found in VEGF expression between the two groups （P〉0.05）. Ki-67 and MVD expressions were higher in the young women group than in the control group （P〈0.01 and P〈0.01）. A positive correlation was found between the Galectin-3 expression and the Ki-67 and MVD （P〈0.01 and P〈0.01）. Conclusion： The high expression of Galectin-3 may contribute to tumor growth and angiogenesis. The metastatic lymph nodes of young women with breast carcinoma showed higher tumor growth, stronger invasion and angiogenesis, which is an important factor for the malignancy and poorer prognosis of breast carcinoma in young women.