力平脂对冠心病患者血尿酸、血脂的影响

The Clinical Study of Lipanthyl Effects on Serum Uric Acid and Lipoid of Coronary Heart Disease Patients

目的观察力平脂对冠心痛不稳定性心绞痛(UA)患者血尿酸(SUA)及血脂的治疗作用。方法96例UA患者随机分为力平脂组(48例)和别嘌呤醇组(48例),疗程为8周,观察治疗前后两组患者临床症状、心电图缺血变化、SUA及血脂的改变。结果①冠心病UA患者SUA升高,血脂异常,治疗前两组SUA、血脂水平相似,治疗后力平脂组、别嘌呤醇组比较差异无显著性(P>0.05),治疗后力平脂组TG,TC,HDL-C,LDL-C与别嘌呤醇组比较差异有显著性(P<0.05)。②力平脂组治疗心绞痛较别嘌呤醇组疗效明显,差异有显著性(P<0.05)。结论UA患者SUA升高,血脂异常,力平脂降SUA作用与别嘌呤醇相当,但调脂作用明显,故能更好地改善UA患者临床症状及心电图缺血改变。

Objective To observe lipanthyl treatment effects on the serum uric acid（SUA） and lipoid of coronary heart disease patients with unstable angina（ UA ）. Methods Ninety-six cases of UA were randomly divided into lipanthyl treatment group（48 cases） and isopurinol treatment group（48 cases） ,the treatment course was 8 weeks,before and after treatment, the clinical symptom, ischemia changes, SUA and lipoid level in both groups were observed and measured. Results ①The level of SUA was high and lipoid was abnormal in patients with UA. After treatment, the level of SUA in lipanthyl group and isopurinol group had no statistics difference between them （ P 〉 0.05 ） , but the level of TG,TC,HDL-C, LDL-C in lipanthyl group had significant statistics difference compared with isopurinol group（ P 〈 0. 05 ）. ②There was significant statistics difference between lipanthyl group and isopurinol group due to angina pectoris （ P 〈 0.05 ）. Conclusion The level of SUA is high and lipoid is abnormal in patients with UA. Lipanthyl, with its comparable lowering effect on SUA and more powerful regulating effect on lipoid compared with isopurinol, has better amelioration clinical symptom, ischemia changes on patients with UA.