核素骨扫描在视网膜母细胞瘤中的应用价值

The value of bone scan in retinoblastoma

目的探讨全身核素骨扫描在视网膜母细胞瘤的转移及预后中的应用价值。方法对2006年8月-2007年2月临床确诊为视网膜母细胞瘤(Rb)的36例患儿,在治疗前进行全身核素骨扫描,观察扫描结果与预后的关系。结果36例患儿中死亡4例,其中3例为骨侵犯或转移,此3例中只有1例脑脊液中发现肿瘤细胞;随访时间10～18个月,平均13.6个月。结论视网膜母细胞瘤的骨转移发生率极低,核素骨扫描不建议作为其首选检查方法;针对晚期病例,核素骨扫描可以对转移和预后作出评估。

Objectives To evaluate bone scan in predicting metastasis and prognosis of retinoblastoma. Methotis Thirty-six （36） eases clinically diagnosed as retinoblastoma in our hospltal were included and were examined with bone scan before treatment. Relationship between results of bone scan and prognosis was analyzed. Results the patients were followed up for average 13.6 months （ranged from 10 to 18 months）. Among 4 died patients, 3 had bone metastasis, 1 died of complication of acute purulent obstructive cholecystitis. Retinoblastoma only found in 1 of these 3 metastasis cases in cerebrospinal fluid. Conclusions Because bone metastasis of retinoblastoma seldom happens, bone scan was not suggested as the first choice of screening method. For an advanced stage patient, a positive result in bone scan indicates high mortality.