P-ERG与盘沿面积测量在原发性开角型青光眼早期诊断中的应用比较

Comparing rim area by HRT-Ⅲ with P-ERG in the early diagosis of POAG

目的观察图形视网膜电图(P-ERG)检查与海德堡视网膜断层扫描仪(HRT-Ⅲ)测量盘沿面积在原发性开角型青光眼(POAG)的早期诊断中的应用价值。方法选择早期POAG患者25例(25只眼),可疑青光眼患者25例(25只眼),正常对照组25例(25只眼),分别进行HRT-Ⅲ及P-ERG检查,观察检查结果异常率,并分析HRT-III盘沿面积与P-ERGN95振幅的相互关系。结果在早期POAG组,P-ERG、HRT-Ⅲ检测异常率分别为72%、32%,差别具有显著意义(P(0.05);可疑青光眼组,HRT-Ⅲ、P-ERG检测异常率分别为20%、60%,差别具有显著意义(P(0.05);正常对照组,HRT-Ⅲ、P-ERG检测异常率分别为20%、12%,差别无显著意义(P(0.05)。在早期POAG组,盘沿面积与N95波振幅在颞上、鼻下、鼻上区存在正相关,相关系数r分别为0.478、0.418、O.444;可疑青光眼组,盘沿面积与N95波振幅在颞下区存在正相关,相关系数r为0.496;正常对照组,盘沿面积与N95波振幅在鼻上,鼻下区存在正相关,相关系数r分别为0.449、0.438。结论在POAG的早期诊断中,P-ERG的检测异常率明显高于HRT-Ⅲ,且盘沿面积与N95波振幅存在一定相关性,联合检查将更有助于POAG的早期诊断。

Objective To observe the diagalostic ability of pattern electroretinogram （P-ERG） and rim area measured by Heidelberg retina tomography Ⅲ[ HRT-Ⅲ ） in the primary open-angle glaucoma （ POAG ）. Methods 25 patients （ 25 eyes） in the early stage of POAG 25 patients （ 25 eyes） with suspected POAG, 25 normal controls were enrolled in the study , and they were measured with-ERG and HRT-Ⅲ. The abnormal rates of P-ERG and HRT-Ⅲ were compared, and the correlation between rim area and P-ERG was investigated. Results In the early stage POAG group, the abnormal rates of P-ERG was 72% ,much more than HRT-Ⅲ（32% ） significantly ;I n the suspected POAG group, the abnormal rates of P-ERG was 60% ,while the rate of HRT-Ⅲ was 20% ; In the normal group, the abnormal rates of P-ERG and HRT-Ⅲ did not have a significant difference, with the abnormal rate of 12 % and 20%. Conclusion The abnormal rates of P-ERG was much higher than HRT-Ⅲ in the early diagnosis of POAG, and the rim area have a positive correlation with P-ERG. P- ERG combined with HRI-Ⅲ may be a useful method to early diagnosis of POAG.