摘要
目的观察原发性急性闭角型青光眼和慢性闭角型青光眼角膜内皮细胞的形态学特点及差异。方法应用非接触型角膜内皮细胞计测量眼压基本控制的18例原发性急性闭角型青光眼18只急性发作眼及对侧18只临床前期眼和20例(26只眼)中晚期慢性闭角型青光眼中央角膜内皮细胞的单位面积细胞密度(CD),最小细胞面积(MIN),最大细胞面积(MAX),平均细胞面积(AVG),平均细胞面积的标准差(SD)和细胞面积的变异系数(CV),并进行对比分析。结果原发性急性闭角型青光眼急性发作眼组和对侧临床前期眼组比较、原发性急性闭角型青光眼急性发作眼组和慢性闭角型青光眼组比较,中央角膜内皮细胞的单位面积细胞密度显著性减少(P<0.01),最小细胞面积、最大细胞面积、平均细胞面积、平均细胞面积的标准差和细胞面积的变异系数均有显著性增加(P<0.01)。结论急性增高眼压对角膜内皮细胞造成显著损害,细胞密度明显下降,细胞多形性增加,损害程度与急性增高眼压持续时间有关;急性增高眼压较慢性增高眼压对角膜内皮细胞的损害更大。
Objective To observe the morphometric changes of the corneal endothelial cells in acute angle-closure glaucoma and chronic angle-closure glaucoma. Methods A total of 18 patients with acute angle-closure glaucoma were divided into two groups： the acute group（eyes in the acute attack stage, IOP were controlled well n = 18 ） and the pre-clinical stage group（ the other eyes in pre-clinical stage, n = 18）. And A total of 20 patients（26 eyes） with chronic tingle-closure glaucoma （vision）were observed（ eyes with medium visual field deterioration or more）. Cell density（CD） , minimum cellular area （ MIN ） , maximum cellular area （ MAX ） , average cellular area of the centre corneal endothelium （ AVG ） , standard deviation of AVG （SD） and coefficient of variation of cellular area （ CV ） were determined by a non-contact specular microscope and a computer aid image analysis system. The statistical significance of the above indexes was analyzed. Results Compared with the pre-clinical stage group and chronic angle-closure glaucoma group respectively, CD were significantly decreased in the acute group（ P 〈0.01 ）, but MIN,MAX, AVG,SD, CV was significantly increased in the acute group （ P 〈0.01 ）. Conclusion Cell density is significantly decreased but cell pantomorphia is significantly increased in eyes of the acute IOP-increased. The damage degree of the corneal endothelial cells in acute angle-closure glaucoma is significantly relate to the time of high IOP.
出处
《临床眼科杂志》
2008年第4期295-297,共3页
Journal of Clinical Ophthalmology
