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经编结构血管外支架的体外降解性能 被引量:1

Degradation of warp knitted external vascular stent in vitro
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摘要 背景:用可降解生物材料制成的外支架能在血管重建之后被人体吸收或排泄,不会造成毒害,但若材料的降解速度过快,强力保持性能差,则无法起到辅助血管重建的作用。目的:采用可降解纤维聚对二氧杂环己酮(polydioxanone,PDS)编织经编结构血管外支架,观察其在体外降解过程中的外观、质量损耗和径向压缩性能。设计、时间及地点:观察对比体外实验,于2007-11/2008-04在东华大学生物医用纺织品研究中心及东华大学材料学院扫描电镜实验室完成。材料:血管外支架由东华大学纺织学院自行制备,采用直径为0.20mm的PDS单丝在小口径圆筒形经编机上编织而成。方法:选用pH值为7.4的生理盐水作为培养液,参照国标GB/T16886.13-2001和国家食品药品监督管理局YY/T0473-2004标准对试样进行体外降解实验。主要观察指标:降解前后支架材料的外观形态、质量损失以及压缩回复性能的变化。结果:表观观察发现,PDS支架在降解8周后表面有明显腐蚀痕迹,降解12周后有破坏痕迹;支架在降解12周后质量开始严重损失;压缩性能测试发现PDS支架在降解12周内的弹性回复率的稳定性较好。结论:PDS纤维的降解时间较长,用其制作的支架压缩性能有较好的稳定性。 BACKGROUND: External stents made of degradable biomaterials are prone to be absorbed or excreted after the vascular restitution, leading no toxicity. Too rapid degradation velocity results in the poor retention of the force, affecting its role as an assist to the vascular restitution. OBJECTIVE: To study the appearance, mass loss and compression force during in vitro degradation of the warp knitted external vascular stent made of degradable polydioxanone (PDS) fibers. DESIGN, TIME AND SETTING: A controlled study in vitro was carried out in the Biomedical Textiles Research Center and Scanning Electron Microscope Laboratory of Material Sciences & Engineering College, Donghua University from November 2007 to April 2008. MATERIALS: External vascular stents were self-made in Donghua University Textiles College by a 0.20-mm diameter of PDS monofilament on small-diameter circular warp knitting machine, METHODS: According to GB/T 16886.13-2001 and YY/T 0473-2004, degradation experiments in vitro were performed in culture medium containing normal saline at pH 7.4. MAIN OUTCOME MEASURES: The appearance, mass loss and elastic recovery of the stents were observed before and after the degradation. RESULTS: The surface corrosion of the PDS stents was evident after 8 weeks of degradation, and there were some damages on the stems at 12 weeks. The mass loss of the stents increased abruptly after 12 weeks of degradation. Compression test showed that the elastic recovery of the PDS stents remained less change within 12 weeks. CONCLUSION: PDS fiber has a relatively long degradable period. The manufactured stents with PDS fiber has a good compression property.
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2008年第27期5248-5252,共5页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 国家自然科学基金资助项目(30571847)~~
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共引文献21

同被引文献24

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