红霉素胸膜粘连术对难治性自发性气胸的治疗价值

Erythromycin-Induced Pleural Adhesions in the Treatment of Refractory Spontaneous Pneumothorax

目的观察红霉素胸膜粘连术对难治性自发性气胸的治疗价值。方法经胸腔闭式引流管注入红霉素到胸膜腔治疗难治性自发性气胸28例为治疗组,以同期28例难治性自发性气胸经胸腔闭式引流治疗为对照组。结果以红霉素为硬化剂的胸膜粘连术治疗方法的治疗组28例复发3例,复发率约为10%。对照组28例复发11例,复发率约为39%,两组间差异有统计学意义(P=0.014)。结论胸腔引流管注入红霉素治疗难治性自发性气胸是简便易行,安全、费用低的一种有效方法,具有一定的治疗价值,可在基层医院推广。

Objective To evaluate the clinical value of using erythromycin-induced pleural adhesions in the treatment of refractory spontaneous pneumothorax. Method 28 patients with refractory spontaneous pneumothorax were treated by injecting erythromycin into the pleural cavity by using a closed thoracic drainage tube. In the control group, 28 patients with refractory spontaneous pneumothorax were treated with the closed thoracic drainage treatment. Result In the group with erythromycin treatment, 3 cases of recurrence （recurrence rate 10%） were noted. In the control group, the recurrence rate was 39%, and the result was significantly different from the treatment group （P= 0.014）. Conclusion Erythromycin-induced pleural adhesion technique is safe and simple to perform. The method is cost effective and should be introduced to other hospitals.