维阿露联合窄谱UVB照射治疗白癜风疗效观察

Observation on the effect of compound Weialu combined with UVB on vitiligo patients

目的观察维阿露联合窄谱UVB照射治疗白癜风的临床疗效和安全性。方法将77例稳定期白癜风患者随机分为4组,试验组外用维阿露联合窄谱UVB照射,对照1组外用维阿露,对照2组单用窄谱UVB照射,对照3组外用卤米松/三氯生乳膏。结果试验组、对照1组、对照2组及对照3组的有效率分别为75.0%、42.1%、42.1%和36.8%,试验组与对照1组、对照2组及对照3组差异均有统计学意义(P<0.05);各组间痊愈率比较,差异均无统计学意义(P>0.05)。就部位而言,试验组头面部有效率优于躯干部(P<0.05),头面部有效率显著优于四肢(P<0.01)。试验组与对照组药物相关不良反应发生率差异无统计学意义(P>0.05)。结论维阿露联合窄谱UVB照射治疗白癜风有效。

Objective To observe the therapeutic effect and safety of Weialu combined with narrow - band UVB on vitiligo. Methods The 77 patients were divided into 4 groups and the treatment group were treated with Weialu combined with narrow- band UVB. The control group 1,2,3 were treated with Weialu alone, narrow- band UVB alone, and Sicorten plus respectively. Results The total effective rates of treatment group, control groupl, control group 2, and control group 3 were 75.0%, 42. 1%, 42.1% and 36.8%, respectively. There were statistical differences of total effective rates between the treatment group and other control groups （P 〈 0.05 ）, while there were no statistical differences in the cure rates among the groups （P 〉 0.05 ）. Better responses were observed on the head and the face （P 〈 0.05 ）. No statistical differences of adverse effects were observed between treatment group and control groups （P 〉 0.05）. Conclusion Weialu combined with narrow - band UVB is effective for treatment of vitiligo.