米非司酮治疗异位妊娠156例疗效观察

The application of mifepristone in treatment of 156 patients with ectopic pregnancy

目的探讨米非司酮在异位妊娠保守治疗中的作用。方法将156例异位妊娠患者(观察组)应用米非司酮治疗,以观察其疗效及不良反应,与48例应用甲氨蝶呤组(对照组)做对照。结果观察组156例患者中,保守治疗成功113例,治愈率72.3%,而对照组48例患者中治愈21例,治愈率41.9%,2组比较差异有统计学意义(P<0.05);2组均于治疗后1周血人绒毛膜促性腺激素开始下降,治疗后2周包块平均直径明显缩小,与治疗前比较差异显著(P<0.05);观察组用药后不良反应明显低于对照组(P<0.05)。结论米非司酮治疗异位妊娠的效果优于甲氨蝶呤,且不良反应小,在异位妊娠保守治疗中有广阔的应用前景。

Objective To explore the efficacy of mifepristone for conservative treatment of ectopic pregnancy. Methods 156 cases were treated with mifepristone compared with 48 cases with methorexate,Results In group of mifepristone, the cure rate was 72,3 %while it was 41,9 %in group of methorexate ,There was statistical significance difference between them. The [3 -hCG of two groups was declined remarkably after 1＇ week of treatment（P〈0.05 ）and mass diameter was decreased remarkably after2 weeks of treatment （P〈0.05）,The adverse drug reaction of group with mifepristone was less than that of group with methorexate （P〈0.05）,Conclusion The effect with mifepristone was better than that with methorexate in treating ectopic pregnancy. There was not adverse drug reaction with mifeprestone, and it could be conveniently used in conservative treatment of ectopic pregnancy.