异甘草酸镁与甘利欣治疗病毒性肝炎疗效比较

Comparison of Curative Effect between Magnesium Isoglycyrrhizinate and Diammonium Glycyrrhizinate on Patients with Virus Hepatitis

目的通过异甘草酸镁与甘利欣对比,观察异甘草酸镁治疗病毒性肝炎的疗效。方法应用异甘草酸镁治疗病毒性肝炎,并与甘利欣注射液作对照。2组各40例,在同样常规综合治疗的基础上治疗组加用异甘草酸镁100mg,1次/d,对照组加用甘利欣注射液150mg,1次/d。观察项目包括症状、体征及肝功能变化,治疗前后检查血常规、尿常规和肾功能,并随时注意药物不良反应。结果异甘草酸镁组与甘利欣组对降ALT、AST的疗效比较,2组差异有统计学意义(P<0.01)。结论异甘草酸镁治疗病毒性肝炎在改善症状和降酶方面疗效更佳。

Objective To investigate the comparison on curative effect between magnesium isoglycyrrhizinate and diammonium glycyrrhizinate on patients with virus hepatitis. Methods 40 patients were divided into two groups randomly： treatment group （40 cases） and control group（40 cases） were treated with routine treatment,and magnesium isoglycyrrhizinate was given once a day in treatment group, diammonium glycyrrhizinate was given once a day in control group. Symptoms, signs and hepatic function were observed. Blood routine examination, urine routine test and kidney function in all patients of two groups were detected before and after treatment,adverse drug reactions were monitored at any time. Results ALT and AST levels in magnesium isoglycyrrhizinate treatment group were lower than that in control group, the difference was significant （ P 〈 0.01 ）. Conclusions The results sug- gested that,in treatment of virus hepatitis, magnesium isoglycyrrhizinate appeared to work better in improving symptoms and decreasing enzyme.