期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

促红细胞生成素的心肌保护作用 被引量：1

下载PDF
导出
摘要 促红细胞生成素（EPO）主要由肾脏皮质髓质交界处的肾小管旁细胞分泌，是一种刺激骨髓造血的糖蛋白类激素，主要作用为促红系祖细胞分化及分裂为成熟红细胞，已广泛用于治疗慢性肾衰、恶性肿瘤、自身免疫性疾病伴发性贫血、骨髓增生异常综合征等疾病所致的贫血。近年来的研究已经证明，不仅肾小管周围间质细胞可以分泌EPO，
作者 刘奇良 于浩
机构地区 上海市普陀区人民医院心内科
出处 《老年医学与保健》 CAS 2008年第4期252-253,共2页 Geriatrics & Health Care
关键词 促红细胞生成素 心肌保护作用 骨髓增生异常综合征 自身免疫性疾病 糖蛋白类激素 细胞分泌 成熟红细胞 骨髓造血
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献17

  • 1Li F, Chong ZZ, Maiese K. Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways. Neurosignals, 2004, 13: 265-289.
  • 2Calvillo L, Latini R, Kajstura J, et al. Recombinant human erythropoietin protects the myocardium from ischemiareperfusion injury and promotes beneficial remodeling. Proc Nail Acad Sci USA, 2003,100: 4802-4806.
  • 3Tramontano AF, Muniyappa R, Black AD, et al. Erythropoietin protects cardiac myocytes from hypoxia-mduced apoptosis through an Akt-dependent pathway. Biochem Biophys Res Commun, 2003,308: 990-994.
  • 4Liu X, Xie W, Liu P, et al. Mechanism of the cardioprotection of rh-EPO pretreatment on suppressing the inflammatory response in isehemia-reperfusion. Life Sci, 2006, 78:2255 -2264.
  • 5Suzuki N, Olneda O, Takahashi S, et al. Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality. Blood, 2002, 100:2279-2788.
  • 6张定国,张馥敏,张郁清,周芳,高翔,李传富,曹克将.促红细胞生成素经磷酸酰肌醇-3-激酶/蛋白激酶B途径增强自体骨髓间充质干细胞移植治疗大鼠心肌梗死的作用[J].中华心血管病杂志,2006,34(10):912-916. 被引量：11
  • 7Parsa CJ, Matsumoto A, Kim J, et al. A novel protective effect of erythropoietin in the infarcted heart. J Clin Invest, 2003,112: 999 - 1007.
  • 8Silverberg DS, Wexler D, Sheps D, et a l. The effect of correction of mild anemiain severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: randomized controlled study. J Am Coll Cardiol, 2001,37: 1775 - 1780.
  • 9Van der Meer P, Voors AA, Lipsic E, et al. Erythropoietin in cardiovascular diseases. Eur Heart J, 2004,25:285-291.
  • 10Lipsic E, van der Meer P, Henning RH, et al. Timing of erythropoietin treatment for cardioprotection in ischemia / reperfusion. J Cardiovasc Pharmacol, 2004,44: 473 -479.

二级参考文献1

共引文献10

同被引文献9

  • 1Curis MJ,Wakler MKA.Quantification of arrhythmias using sco-ring susrems:An examination of seven scores in an invivo model of regional myocardial ischemia.Cardiovasc Res,1988,22(9):656-665.
  • 2Ravingerov T,Tribulova N,Slezak J,et al.Brief,intermediate and prolonged ischemia in the isolated crystakkoid perfused rat heart:Relationship between susceptibility to arrhythmias and degree of ultratruclural injury.J Mol Cardiol,1995,27(9):1937-1951.
  • 3Joyeux-Faure M.Godin-Ribuot D,Ribuot C.Erythropoietin and myocardial protection:wha's new?.Fundam Clin Pharmacol,2005,19(4):439-446.
  • 4Feagan BG.Wong CJ,Kirkley A,et al.Erythropoietin with iron supplementation to prevent allogeneic blood transfusion in total hip joint arthroplasty.A randomized,controlled trial.Ann Intern Med,2000,133(11):845-854.
  • 5Ghezzi P,Brines M.Frythropoietin as an antiapopototic,tissue protective cytokine.Cell Death Differ,2004,11(6):s37-44.
  • 6HuntsmanI DG,Cameiro F,Lewis FR,et al.Early gastric cancer in young,asymptomatic carriers of germ-line E-cadherin mutations.New Engl J Med,2001,344(25):1904-1909.
  • 7Chan JK,Wong CS.Less of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast.Adv Anat Pathol,2001,8(3):165-172.
  • 8徐秋琴.促红细胞生成素对缺血性心脏病作用的研究进展[J].杭州师范学院学报（医学版）,2007,27(6):403-407. 被引量：2
  • 9钱俊,张亚臣.再灌注心律失常的发生机制、类型与治疗[J].心血管病学进展,2008,29(4):567-570. 被引量：27

引证文献1

二级引证文献3

老年医学与保健
2008年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部