肺血管重塑与低氧性肺动脉高压

Pulmonary vascular remodeling and hypoxic pulmonary hypertension

肺血管重塑和肺动脉高压密切相关，慢性缺氧是肺血管重塑和肺动脉高压的一个常见原因。肺血管重塑以纤维母细胞、平滑肌细胞和内皮细胞增殖为最大特征，并导致管腔闭塞。了解肺血管重塑特征和机制对于预防或者逆转肺动脉高压具有重要的意义。

Pulmonary artery hypertension is associated with pulmonary vascular remodeling, a common cause of which is chronic hypoxia. Pulmonary vascular remodeling is characterized by the proliferation of fibroblast, smooth muscle ceil and endothelium cell, causing obliteration of lumina. To investigate the characteristics and mechanism of pulmonary vascular remodeling is important to prevent and reverse pulmonary artery hypertension.