缬沙坦和美托洛尔对老年高血压患者血浆内皮素和一氧化氮的影响

Effect of valsartan and metoprolol on plasma endothelin and nitric oxide in elderly patients with essential hypertension

目的了解缬沙坦和美托洛尔对老年高血压患者血浆内皮素(ET)、一氧化氮(NO)的影响。方法将67例老年高血压患者随机分为2组,分别服缬沙坦和美托洛尔治疗8周,观察服药前后血压及血浆ET、NO的变化。结果治疗后2组血压明显下降(P<0.01),以缬沙坦组下降较为显著;缬沙坦组血浆ET明显下降(P<0.01),NO显著升高(P<0.01),而美托洛尔组血浆ET及NO无明显改变。结论缬沙坦不仅有良好的降压作用,同时有较好的血管内皮保护功能。

Objective To explore the effect of valsartan and metoprolol on plasma endothelin （ET） and nitric oxide （NO） in elderly patients with essential hypertension （EH）. Methods Sixty-seven elderly patients with EH were randomly divided into two groups and treated with valsartan or metoprolol for eight weeks. The levels of blood pressure, ET and NO levels were detected and analyzed. Results After treatment, the blood pressure of the two groups decreased significantly （P 〈0.01 ）. The plasma level of ET decreased significantly （P 〈0.01 ） and the plasma level of NO increased sig- nificantly in Valsartan group （P 〈 0. 01 ）. Conclusions Valsartan might not only prevent EH from development but also prevent vascular endothelium from being damaged in EH.