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全麻药对大脑发育毒性作用的研究进展 被引量：1

Advance in neurotoxicity of general anesthetics to brain development
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摘要 近年来的研究发现，在未成熟哺乳动物大脑的快速生长期，暂时拮抗N-甲-（D）-天（门）冬氨酸（NMDA）受体或过度兴奋γ-氨基丁酸（GABA）受体可诱发大脑神经元的大量凋亡。通过此机制引起大脑快速生长期未成熟神经元凋亡的药物包括全麻药、抗惊厥药和一些滥用药。人类快速发育期的大脑有许多接触镇静药、全麻药、抗惊厥药的机会。现以全麻药为重点对这些研究发现作一简要综述。 Transient blockade of glutamate N-methyl-D-aspartate （NMDA） receptors or excessive activation of GABAA receptors may trigger neuronal apoptosis in immature mammalian brain during the period of rapid brain growth. It has been shown that anesthetics, anticonvulsants, and drugs of abuse may induce apoptotic neurodegeneration via same mechanism and may affect the development of human brain.
作者 孙正清 杨天德
机构地区 解放军第 第三军医大学新桥医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2008年第4期349-351,356,共4页 International Journal of Anesthesiology and Resuscitation
关键词 N-甲-(D)-天(门)冬氨酸受体 γ-氨基丁酸A型受体 全麻药 凋亡 发育 NMDA receptors GABAA receptors general anesthetics apoptosis brain development
分类号 R96 [医药卫生—药理学]
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参考文献24

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同被引文献22

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国际麻醉学与复苏杂志
2008年 第4期

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