利多卡因与神经病理性疼痛

Lidocaine and neuropathic pain

神经病理性疼痛是一种严重影响人类健康的疼痛性疾病，至今仍缺乏有效的治疗手段，其机制也未能完全阐明。大量临床和实验研究证实，局部麻醉药利多卡因对多种神经病理性疼痛有明显的疗效。正如慢性神经病理性疼痛机制的复杂性一样，利多卡因对慢性神经病理性疼痛的镇痛机制也不是单一的，此文就利多卡因对神经病理性疼痛镇痛机制研究的进展作一综述。

Chronic neuropathic pain is a serious pain disease which is difficult to cure, and the mechanisms are not yet fully clear. Masses of clinical and experimental studies have shown that lidocaine has therapeutic effect on many neuropathic pain diseases. As a nonspecific sodium channel blocker, lidocaine suppresses conduction of pain signal not only by affecting the ectopic discharge of primary sensory neuron, but also by other very complicated mechanisms.