胆囊癌肉瘤1例报告并文献复习

Carcinosarcoma of Gallbladder:A Case Report and Literature Review

目的:探讨胆囊癌肉瘤的临床病理特征、诊断及鉴别诊断、治疗、误诊的原因和预防。方法:分析1例胆囊癌肉瘤的临床表现,对标本进行组织病理学和免疫组织化学染色观察,并复习文献,了解该肿瘤的特征。结果:胆囊癌肉瘤罕见,女性多于男性,恶性度高,预后差。组织学检查显示有癌和肉瘤成分,免疫组织化学对鉴别诊断有帮助。手术及放、化疗均疗效不好。结论:原发于胆囊的癌肉瘤较罕见,预后与肿瘤分期有关。临床实践中要特别重视本病与胆囊的一些相似疾病鉴别。避免误诊。

Objective：To investigate the clinical and pathological characteristic,diagnosis,differential diagnosis, treatment, reasons and prevention of misdiagnosis of gallbladder careinosarcoma. Methods,, The clinical findings, histopathology and immunohistochemistry of a gallbladder carcinosarcoma were studied and the relative literature was reviewed in order to understand the characteristics of the tumor. Results ：Carcinosarcoma is a extremely rare ,high malignant neoplasm of gallbladder and often occurs in middle aged female, Histologically ,it showedintimate admixture of carcinoma and sarcoma,Immunohistochemical staining was helpful in confirming the diagnosis. Better clinical effect could not be achieved by either operation or radiotherapy,chemo therapy. Conclusion：Primary carcinosarcoma of gallbladder is a rare tumor. The poor prognosis is correlated with stage of the tumor. More attention should be paid in the daily practice in order to differentiate this tumor from other similar diseases of the gallbladder,avoid misdiagnosis.