摘要
综述了BMP15在哺乳动物生殖系统中的表达和生物学作用,提示BMP15在垂体中表达并促进FSH的合成。在卵巢中由卵母细胞特异性分泌,促进颗粒细胞增殖并抑制FSH依赖性细胞分化。在一些物种中BMP15的变异会造成多胎或者不育,显示BMP15是影响哺乳动物生殖的重要因子。建议继续探讨BMP15的作用机理,同时研究其在其他物种中的变异对生殖的影响。
In this paper, expression and biological function of bone morphogenetic protein 15 （BMP15） in mammalian reproductive system are summarized. BMP15 is expressed in the pituitary and promotes the synthesis of FSH. Secreted specifically by oocytes, it promotes the generation of granular cell and inhibits the differentiation of FSH-dependent cells.Mutations of BMP15 may cause muhiplets or sterility in some species, indicating that BMP15 is an important factor regulating animal reproduction. It is necessary to investigate the mechanisms of BMP15 functions and the effect of mutations on reproduction in other species.
出处
《动物学杂志》
CAS
CSCD
北大核心
2008年第4期140-145,共6页
Chinese Journal of Zoology
基金
山东省自然科学基金项目(No.Y2006D24)
