心室辅助循环后心肌间质变化的研究进展

Progress in Studies of Changes in Myocardial Interstitium after Ventricular Assist Circulation

心室辅助使心室处于无负荷状态,改善缺血心脏血流动力学及能量代谢状况,不仅使心力衰竭引起的多器官功能衰竭得到改善,还使心脏功能及心肌细胞的损伤得到恢复。近年来通过对心肌间质的研究发现,心室辅助循环对心肌间质中的主要结构蛋白-型、型胶原及其代谢调节系统产生影响,使心肌间质胶原含量及分布发生变化,从而逆转不利的心肌间质重构,改善心功能。现就这一主题的相关研究进行综述。

Ventricular assist device can provide the heart with a non-load circumstance and improve hemodynamics and energy metabolism of ischemic myocardium. With ventricular assistance,not only multiple organ failure is improved but also cardiac function and myocardial injury are resumed. In recent years, studies found that ventricular assistance have an impact on the myocardial interstitium on its structural protein type I ,Ⅲ collagens and their metabolism conditioning systems. It reverse adverse myocardial remodeling and improve cardiac function by changing myocardial collagen content and distribution.