通心络对不稳定型心绞痛患者血管内皮生长因子水平影响的研究

Effect of Tongxinluo on Serum Vascular Endothelial Growth Factor Level in Patients with Unstable Angina Pectoris

目的:探讨通心络治疗动脉粥样硬化的机制。方法:92例不稳定型心绞痛患者随机分为常规治疗组(未服用通心络及任何调脂药物,40例)和通心络组(760mg,3次/d,52例),测定治疗前及治疗后14d患者血清血管内皮生长因子(VEGF)和血脂水平的变化。结果:通心络组患者治疗后14d血清VEGF水平降低38.5%,与治疗前比较差异有统计学意义(P<0.01)。2组治疗前后TC和LDL-C均下降,但组间比较差异无统计学意义(P<0.05),通心络组治疗后HDL-C升高(P<0.05)。在通心络组,VEGF的下降百分数与TC、LDL-C的下降百分数和HDL-C的升高百分数之间无相关性(r分别为0.10、0.06和-0.01,均P>0.05)。结论:短期通心络治疗可明显降低不稳定型心绞痛患者血清VEGF水平。通心络可通过改善斑块稳定性达到抗动脉粥样硬化的作用。

Objective： To observe the influence of Tongxinluo on serum VEGF level in patients with unstable angina pec＇toris. Methods： Ninety-two patients with unstable angina pectoris were randomized to either Tongxinluo group （760 mg,3/ d;n=52） or control group （no lipid-lowering drugs; n=40）. Serum levels of VEGF and lipids were detected before and after treat-ment. Results： Serum levels of VEGF were significantly decreased 38.5% by Tongxinluo. Levels of serum TC and LDL- C were dec/eased before and after treatment in beth groups and levels of serum HDL-C were increased in Tongxinluo group. There were no correlation between the decrease percent of TC, LDL-C and that of VEGF. There was no correlation between the increase percent of HDL-C and the decrease percent of VEGF. Conclusion： Tongxinluo decreased serum level of VEGF in patients with unstable angina pectoris, whereas it may benefit to atherosclerotic plaque stabilization.