系统性红斑狼疮患者合并感染的危险因素分析

Analysis of the Risk Factors for Infection in Patients with Systemic Lupus Erythematosus

目的:探讨系统性红斑狼疮(SLE)合并感染的危险因素。方法:采用回顾性调查方法,通过单因素和多因素logistic回归方法对合并感染的SLE患者的病例资料、实验室检查、病情活动性和治疗经过进行分析。结果:SLE患者合并感染的发生率为51.4%,感染发生的常见部位为呼吸道和泌尿道,条件致病菌感染有增加趋势。多因素分析表明激素冲击治疗、年龄、应用广谱抗生素、住院时间延长、病情活动性与感染的发生密切相关(P<0.05)。结论:感染是SLE患者常见合并症,也是导致患者死亡的重要原因。特殊治疗方法、病情活动以及抗生素的不合理应用与感染的发生有直接关系。有效的预防和控制感染可以改善SLE患者的预后。

Objective： To investigate the risk factors for infection in patients with systemic lupus erythematosus （SLE）. Methods： Using the retrospective investigation, single and multiple factors logistic regression analysis was conducted to analyze the clinic data, laboratory examination, disease activity and treatment in patients with SLE. Results： The incidence of infection in patients with SLE was 51.4%, the common infection sites were respiratory tract and urinary tract, and infection of opportunistic pathogens had an increasing trend. Multifactor analysis showed that methylprednisolone pulse therapy, age, application of broad spectrum antibiotic, prolonged time of hospitalization and disease activity were closely related with infection （P 〈 0.05）. Conclusion： Infection is the common complication in patients with SLE, which is also the important cause of death. Special therapy, disease activity and unreasonable application of antibiotic have a direct relationship with infection. Effective prevention and control of infection can improve the prognosis in patients with SLE.