成嗅神经细胞瘤36例的治疗及预后

Therapeutic effects of 36 patients with esthesioneuroblastoma and their prognosis

目的：探讨成嗅神经细胞瘤（esthesioneuroblastoma，ENB）的不同的治疗方案及预后。方法：36例ENB患者，单纯手术治疗2例．单纯放射治疗2例，综合治疗32例。综合治疗包括手术结合放射治疗14例，放射治疗结合化学治疗6例，手术结合放疗化疗12例。随访时间2-60个月，中位随访时间48个月，应用SPSS 13．0软件包进行统计分析。结果：5年生存率55．6％，有无颈部淋巴结转移的患者5年生存率差异有统计学意义（P〈0．05）。结论：早期发现和综合治疗对改善生存率有重要意义，颈部淋巴结转移是预后的重要影响因素，放射治疗在ENB的治疗中占有重要地位。

Objective：To study the different treatment policies for patients with esthesioneuroblastoma （ENB） and their prognosis. Methods：Thirty-six ENB patients included 20 males and 16 females at average age of 46 years old （24-74 years）. Two patients received single surgery and 2 patients received single radiotherapy. Thirty-two patients received combined therapy, which included surgery plus radiotherapy （ n = 14） , radiotherapy plus chemotherapy （ n = 6） , surgery plus radiotherapy and chemotherapy （ n = 12 ）. All the patients were followed up for 2-60 months and the median follow-up period was 48 months. Statistic analysis was performed using software SPSS 13. 0. Results ： The overall 5-year survival rate was 55.6%. The 5-year survival rates of patients between patients with and without cervical lymph nodal metastasis were statistically significant （P 〈 0.05 ）. Conclusion：Early detection and combined therapy are important to improve survival rate. Cervieal lymph node metastasis is significantly correlated with the prognosis. Radiotherapy plays an important role in the management of the disease.