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TC21/R-Ras 2在肿瘤中的研究进展 被引量：1

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摘要 TC21/R-Ras2是RAS原癌基因家族的成员之一,与人的多种肿瘤如乳腺癌、食管癌和口腔癌的形成密切相关,研究表明其在不同的组织、细胞系中通过不同的信号转导通路,例如PI3K-MAPK、MAPK-mTOR、PI3K/AKT等,促进肿瘤的形成、细胞的恶性转化以及转移。
作者 罗海荣 郝向芳 李锦军
机构地区 复旦大学上海医学院 上海交通大学肿瘤研究所癌基因及相关基因国家重点实验室
出处 《肿瘤》 CAS CSCD 北大核心 2008年第8期723-725,共3页 Tumor
基金 国家自然科学基金项目(编号:NSFC/RGC30731160004)
关键词 肿瘤 信号转导 TC21/R—Ras2
分类号 R730.2 [医药卫生—肿瘤]
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参考文献19

  • 1LOME D G, GOEDDEL D V. Heterologous expression and characterization of the human R-Ras gene product [J]. Mol Cell Biol, 1987,7 (8) :2845-2856,
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二级参考文献10

  • 1CLARK G J,KINCH M S,GILMER TM,et al.Overexpression of the fas-related tc21/r-ras2 protein may contribute to the development of human breast cancers[J].Oncogene,1996,12 (1):169-176.
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  • 6ERDOGAN M,POZZI A,BHOWMICK N,et al.Signaling pathways regulating TC21-induced tumorigenesis[J].J Biol Chem,2007,282(38):27713-27720.
  • 7DRIVAS G T,SHIH A,COUTAVAS E,et al.Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line[J].Mol Cell Biol,1990,10(4):1793-1798.
  • 8KIMMELMAN A,TOLKACHEVA T,LORENZI MV,et al.Identification and characterization of r-ras3:A novel member of the ras gene family with a non-ubiquitous pattern of tissue distribution[J].Oncogene,1997,15 (22):2675-2685.
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  • 10OHBA Y,MOCHIZUKI N,YAMASHITA S,et al.Regulatory proteins of r-ras,tc21/r-ras2,and m-ras/r-ras3[J].J Biol Chem,2000,275 (26):20020-20026.

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肿瘤
2008年 第8期

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