乌司他丁综合治疗急性胰腺炎的临床观察

Ulinastin in treatment of acute pancreatitis

目的:观察乌司他丁治疗急性胰腺炎的临床效果.方法:急性胰腺炎患者60例随机分为实验组和常规组,治疗前和治疗后7d分别查患者血清IL-6,TNF-α,C反应蛋白CRP,脂肪酶LIS和AMS.结果:实验组和常规组总有效率依次为94.4%,79.2%,实验组全身炎症反应情况改善时间缩短,与常规组相比,差异具有统计学意义(P<0.05).经治疗7d后,实验组和常规组两组IL-6,TNF-α,CRP,AMY,LIP水平均下降,与治疗前相比差异均具统计学意义(P<0.05),与常规组治疗后相比,实验组下降更快,差异亦具有统计学意义(P<0.05).结论:乌司他丁治疗急性胰腺炎疗效肯定,可改善患者全身炎症反应.

AIM： To observe the curative effect of ulinastain on acute pancreatitis. METHODS： Sixty patients with acute pancreatitis were randomly divided into experimental group and routine treatment group. Serum AMY,LIP,CRP ,TNF -α and IL-6 levels were measured on admission day and the seventh day in both groups. RESULTS： The clinical efficiency rate of experimental group and routine treatment group was 94.4% and 79.2% respectively. Systematic inflammatory reaction alleviated more rapidly in experimental group than in routine treatment group. A statistical significant difference was found between the two groups （ P 〈 0.05 ）. Serum AMY, LIP, CRP, TNF-α and IL-6 levels were obviously decreased with significant difference between the two groups（P 〈0.05）. CONCLUSION： The curative effect of ulinastain on acute pancreatitis is affirmative. It alleviates the systematic inflammatory reaction.