影响帕金森病非运动症状发生的主要因素

Dominant factors impacting on non-motor symptoms in Parkinson's disease

目的研究帕金森病(PD)非运动症状(NMS)分布状况和影响NMS发生数的主要因素。方法对128例PD患者(PD组)和健康成人(对照组)进行NMS问卷(NMSQuest)调查,比较PD组和对照组各项NMS的分布,并结合临床特征等因素分析NMS发生的最主要影响因素。结果PD组与对照组的NMS发生数的差异有统计学意义(P<0.01)。平均每例PD患者有12项NMS,NMS分布于临床各期。多元逐步回归分析显示Hoehn-Yahr分期是影响NMS发生数的唯一因素,起决定作用的占34.1%。结论NMS普遍存在于PD临床各期,其发生数随疾病严重程度的加重而显著递增。NMSQuest应常规用于PD NMS的筛选。

Objective To evaluate the distribution of non-motor symptoms（NMS） and dominant factors impacting on the prevalence of NMS in Parkinson＇s disease（PD）. Methods The NMS questionnaire（NMSQuest） was administered to 128 patients（PD group） and 128 healthy adults（control group）.The distribution of items of NMS was analyzed between the two groups,and clinical characteristics were also collected to assess the dominant factors impacting on the prevalence of NMS. Results There were significant differences in the prevalence of NMS between the two groups（P〈0.01）.Each patient with PD had an average of 12 NMS throughout the disease stages.It was revealed by multiple stepwise regression analysis that the only dominant factor influencing the prevalence of NMS was Hoehn-Yahr staging,which account for 34.1% of the variance of the prevalence of NMS. Conclusion NMS are more commonly occurred throughout the stages of PD.The prevalence of NMS significantly increases with the severity of disease.NMSQuest shall be routinely used in as a screening tool for PD.