摘要
Toll样受体(TLR)是近年来倍受关注的一种病原识别受体,可特异地识别病原相关分子模式,通过激活信号级联反应产生细胞因子和相关刺激因子,从而在天然免疫和获得性免疫中发挥重要的桥梁作用。近年来,TLR4在肝脏缺血/再灌注(I/R)损伤等非病原微生物性炎症和肝再生中的作用也日益受到重视,已知其参与肝脏I/R损伤的部分炎症反应,但其是否参与肝再生过程有待进一步研究。
Toll-like receptor （TLR） is a family of pathogen recognition receptors that can recognize pathogen-associated molecular patterns（PAMPs） , innate signal cascade reaction to produce cytokine and stimulating factors. Accordingly,TLR builds significantly bridge-effect between innate immunity and the adaptive immune response. TLR4 activation has been demonstrated to play a role in hepatic ischemia/ reperfusion （I/R） injury and liver regeneration increasingly. Recently, multiple studies have shown that both inflammation and injury responses in hepatic I/R injury are partially TLR4 dependent, but whether and how TLR4 initiate liver regeneration is not clear.
出处
《国际药学研究杂志》
CAS
2008年第4期267-270,共4页
Journal of International Pharmaceutical Research
